Can you get 300 hp from a 2 barrel carb?

[Gregski]

Some old timers say that the most common mistake is over carbing your engine, so I am just wondering if you can build a modest streetable 300 horse power 302 V8 engine under a two barrel carburetor, or do I need to be looking for a four barrel?

I have the Motrocraft 2150 carb on mine with the 1.21 venturi size which crresponds with 351 CFM according to this chart, but they go up to 424 CFM.

These numbers are for 2V carburetors only (2100/2150). The first numbers are the Venturi Size, the second is the corresponding CFM.

.98 = 190
1.01 = 240
1.02 = 245
1.08 = 287
1.14 = 300
1.21 = 351
1.23 = 356
1.33 = 424