I've got a 351W in my 65 coupe and would highly recommend it. That much hp and torque in such a light car is crazy, and the performance potential for these motors is extemely high.
A word of caution though....
You have to make sure to use a set of 66 motor mounts when you install it (earlier maounts make the engine sit up too high)
Depending on what year 351 you get, the radiator outlets and inlets may not line up with the stock radiator in the car, that may also be a problem.
Also, underhood space is pretty tight, this makes header install and even just getting to the spark plugs a bit more of a chore.
For the most part, it's an easy swap. And as far as I know, it is the largest small block that can be wedged into a 65-66 body without shock tower mods (if you want more cubes you can still stroke it out to 427). I'm not positive, but I think the 351C is too big as well.
Build a 427 stroker.... that would be so bada$$.... 
later
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1965 Coupe: 351W, comp cam, Aluminum Systemax II heads (2.02/1.60), 1.7 Cobra full roller rockers, Edelbrock intake, Holley 650 double pumper, Mallory Unilite, MSD-6AL, MSD Blaster 2 coil, MSD heli-core plug wires, Hedman headers, 2 1/2" exhaust (GT style) w/ 40 series delta flows, 69 C4 w/ shift kit, shelby traction bars, 3.55:1 rear
Daily Driver:
1989 GT- 5spd, K&N (no silencer), Shorty Headers, King Cobra Clutch, Flowmaster Force II Cat-back
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