I dont think a sealed cabin and some kind of knock out gas is a real good solution. Too risky. One little sealed flight deck leak and knock out gas(is there even such a gas to knock people out temporarily?) taking out the pilot would be a great risk.
Air planes fly through the air at tremondous speeds and altitudes, with a lot of stress on the airframe. This causes flexing. Like your uni-body mustang if you will. Aircraft are of a "uni-body" design style. They have to save weight for obvious reasons, and I would bet this is where the automobile industry got the idea for uni-body style framework on cars. Just like aircraft have had anti-lock brake technology that the cars are using now for a long time already.
Anyway, it would be hard to seal off the flight cabin so tightly to elimante the risk of gassing yourself.
I think the best idea I have heard is arming the flightcrews with guns or stun guns. This isnt the definitive answer eithier, but certainly a start. I guess then everybody would say the risk of an armed crew member goping whack-o and taking some people, or the fact of the high-jacker could obtain the weapon and use it againt them.
How about a stun gun with a code needed to arm it?
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