Don't be discouraged, the cast type pistons can be run with Nitrous, Forged is a better choice however. A motor built with forged will be noise until it warms up and the aluminum expands ever so slightly. Something to consider. If you go with the juice run a conservative set-up lots of reduced timing and run a richer set up with injectors to offset burning a piston same would be advised for a blower set-up.
A cooler plug also helps but the biggest is running rich and taking some timing out get some help from a good shop, in your local area, that knows there stuff and you will be fine. 
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393,9.5" 351W,830 Holley,Victor Jr,Home made Cool Air Pan,
Pro Billet MSD,
MSD 6AL,
XE 284H Xtr-Com cam,
240-246 @.050,
540-544,
M/T Et streets,
Mac Upper and Lower, Control Arms,
3:73 US Gear,Mini Spool,
Eagle Long rods,
Mac Windage tray,
KB Pistons,
Scat crank,
4000 rpm stall convertor,
C-4 trans,
Airflow Research 185cc,
Hooker long tubes 3", exhaust,
S&W 6 point roll cage,
11.2 at 121 mph.
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