The same rules apply to 4.6's as 3.8L's. If you go up to 9lbs on the street you will probably be fine, i'd personally opt for a roots style supercharger (eaton), so a kit from Kenne Bell (i believe they make kits for 3.8's but i'm not sure) would be ideal since they make boost instantly off idle, but still a vortech is always a good choice and probably the most popular for V6's. The 3.8's have always had head sealing issues, but i believe in the late 90's they reduce the size of the coolant passages around the cylinders for a more rigid block (what they did in the super coupe 3.8's) and so it's less likely you'll blow a head gasket.
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2005 Suzuki Hayabusa GSX1300-R
1980 Ford Thunderbird - 255 V8
ported heads, 5.0L ported stock headers, O.R. H-pipe and Flowmaster 2-chambers, dual roller timing chain
hi-po Mack Truck hood emblem 
1985 Mustang GT 5.0L T5, F-303, GT40p, headers, off-road h, flowmasters, MSD stuff, etc.
Sold 02/06/04 
1989 Mustang GT ET: 13.304@102.29 mph (5-24-03)
Sold - 1998 Mustang Cobra coupe, 1/4 mile - street tires: 13.843@103.41 (bone stock)
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