3.3 I6 to a 5.0 V8?

if you could give me more info on he 300 cu inch inline six that would be get. my dad has one in his F-150 and they thing is bloody strong. i would kinda like to keep 3.3 cause not many people here run it and i want to be different (whats the point of having a car just like everyone else). what would tranny and rear-end would i want to use? thank you for any info sent.